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cAMP then activates Protein Kinase A (PKA) and Rap Guanine Nucleotide Exchange Factor 4 (RGNEF4), both of which function for rising intercellular Ca2+ levels

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some randomized controlled trials demonstrated that liraglutide, dulaglutide, semaglutide, and albiglutide reduced the rate of CV events in T2DM patients (6–9), while other clinical trials concluded that lixisenatide and exenatide did not significantly improve CV outcomes in such patients (10, 11)